WebApr 10, 2024 · Many drugs used to treat psychiatric disorders, specifically antidepressants and antipsychotics, have been implicated in Q-T interval prolongation and torsades de pointes.
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WebFor people with LQTS there are specific medications that can have a serious effect by further prolonging the QT interval. We give a list of these medicines below. ... Psychiatric drugs Tricyclic antidepressants: amitriptyline, amoxapine*, clomipramine, desipramine*, doxepin, imipramine, nortriptyline, protriptyline*, trimipramine WebFirst-generation antipsychotic medications: Pharmacology, administration, and comparative side effects … death, believed in most cases to be caused by QT prolongation, has been … the valleys of towson
04. Medications That Cause QT Prolongation Hospital Handbook
WebMay 15, 2024 · The prolongation of the QT interval on electrocardiogram is a rare but known risk of some psychotropic (and other) medications. A prolonged QT interval can increase the risk of Torsades de Pointes, a ventricular arrhythmia that can be fatal. Nonpsychiatric drugs that are well known for causing QTc prolongation, such as sotalol and dofetilide, extend the QTc interval by 30 to 40 ms.4 It is agreed that this extension of the interval is clinically significant.4 Clinicians continue to debate whether a lower threshold would be clinically significant. Drugs … See more The QT interval represents the summation of cardiac action potentials.2 Drug-induced QT prolongation is thought to be caused by the inhibition of the delayed potassium rectifier … See more The majority of patients who develop drug-induced QT prolongation also have multiple risk factors (TABLE 1).1 A study evaluating the frequency of risk factors for drug-induced TdP … See more Pharmacists and other clinicians should consider the following recommendations when managing antidepressants and antipsychotics8: 1. Identify risk factors for QT prolongation (TABLE 1). 2. When multiple risk factors … See more The antidepressants and antipsychotics that are correlated with a higher risk of QT prolongation are listed in TABLE 2.TABLE 3 includes … See more WebMar 1, 2024 · Clinicians should approach the decision to prescribe a psychotropic with known risk of QTc prolongation using a comprehensive risk-benefit analysis, including, … the valleys pcn limited