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WebJun 8, 2024 · Divided Dose: 2.5 mg orally every 12 hours for 3 doses once a week Maximum dose: 30 mg/week Comments: Once optimal clinical response has been achieved, each dosage schedule should be reduced to the lowest possible amount of drug and to the longest possible rest period. WebMar 8, 2016 · mable91367. I will start taking Methotrexate 3 tablets (2.5mg) once per week. My doctor told me to pick a day of the week. So I will start on Saturday. I will also be taking folic acid (1 mg) on the alternate days. This will be my 3rd medications. So far, I have taken Azathioprine, Azulfidine and Leflunomide.

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