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Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli

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Hedgehogシグナルを標的とする抗がん薬開発 - 日本郵便

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"Web22 nov 2011 · The Hh ligands (Sonic Hh, Indian Hh, and Desert Hh) bind to the receptors Patched1 and Patched2, resulting in inhibition of their repressive effect on Smoothened (Smo). Smo is a seven-transmembrane protein, which was only recently shown to function as a G protein-coupled receptor (GPCR) with specificity toward the heterotrimeric … " - Hh indian's

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Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli ... - PubMed

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Web18 lug 2008 · The Hedgehog (Hh) signaling pathway, which is well conserved even in mammals and other vertebrate species, has long been known to direct growth and patterning during embryonic development (Pasca di Magliano and Hebrok 2003; Ruizi et al. 2002; Wechsler-Reya and Scott 2001).The Hh pathway consists of Hh proteins, (Sonic …

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