WebRetroviral vectors are significant for basic biological investigations such as studies of cell lineage, mechanisms of carcinogenesis, and developmental and tissue-specific … Human foamy virus (HFV) is a retrovirus and specifically belongs to the genus Spumavirus. The spumaviruses are complex and significantly different from the other six genera of retroviruses in several ways. The foamy viruses derive their name from the characteristic ‘foamy’ appearance of the cytopathic effect … See more The first description of foamy virus (FV) was in 1954. It was found as a contaminant in primary monkey kidney cultures. The first isolate of the “foamy viral agent” was in 1955. Not too long after this, it was isolated … See more If, in fact, HFV is not pathogenic in humans and is a retrovirus, it is an ideal vector for gene therapy. Another important feature of the virus is that the Gag, Pol, and Env proteins are synthesized independently; this is important because it means that each … See more Most of the differences between the spumaviruses and the other retroviruses come from the life cycle. Some of the main differences are that … See more Persistence in the absence of disease, but in the presence of antibodies is a defining characteristic of FV infection. HFV has been isolated from patients with various neoplastic and … See more • Human+foamy+virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more

Foamy virus vector integration sites in normal human cells

WebJul 1, 2016 · Foamy virus vector (FVV) mediates high and sustained expression of ARSA in mMSCs. (a) Lysates of m-MSC transduced cells were taken at each passage from 1 to 5 post-transduction. Lysates were mixed with σ-nitrocatechol sulphate in conditions that specifically enable hydrolysis to be catalyzed by ARSA. The nmol of substrate … WebAug 14, 2008 · Foamy virus vector integration sites in normal human cells. Proc Natl Acad Sci USA 2006; 103 : 1498–1503. CAS Article Google Scholar bios password leader computer

In-Vivo Gene Therapy with Foamy Virus Vectors - ResearchGate

WebDec 5, 2016 · The characterization of natural foamy virus vectors is largely described by the laboratories of Dr Maxine Linnial, Dr Ali Saïb and Dr Axel Rethwilm, as well as … WebJan 20, 2006 · Foamy viruses (FVs) or spumaviruses are retroviruses that have been developed as vectors, but their integration patterns have not been described. We have performed a large-scale analysis of FV integration sites in unselected human fibroblasts ( n = 1,008) and human CD34 + hematopoietic cells ( n = 1,821) by using a bacterial shuttle … WebMar 6, 2024 · Foamy virus isolates were named according to the revised taxonomy 22 and short names were used for gorilla and chimpanzee ... Y.C. produced and assessed Foamy virus vector particles in infection ... bio spear