Diversity outbred
WebAug 15, 2012 · The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display ... WebThe Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically …
Diversity outbred
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WebThe scientists found that, like humans, each Diversity Outbred mouse developed at The Jackson Laboratory, Bar Harbor, Maine, responded to the effects of the chemical exposure differently. Exposure responses were … WebMar 3, 2024 · The Diversity Outbred (DO) mice were derived from CC mice outcrossed to maintain the distribution of alleles from across the eight parental strains in a unique combination in each mouse (Chesler et al., 2016; Saul et al., 2024; Svenson et al., 2012). Each DO mouse is unique, and the population is heterogeneous, giving theoretically …
WebAug 19, 2015 · Diversity Outbred (DO) mice are derived from incipient Collaborative Cross strains and represent a complementary resource with the same allelic diversity as the CC strains, maintained in a heterogeneous stock (Churchill et al. 2012; Chesler 2013). This population is an ideal resource for genetic mapping and selective breeding studies. WebNov 4, 2024 · To determine the effect of genetics on plasma protein levels in human, one needs a rather large sample size. To overcome this critical issue, a mouse model, the Diversity Outbred (DO), was established that is genetically as diverse as the human population. In this study, we used N=140 DO mice and genotyped over 140,000 variants.
WebApr 15, 2024 · In contrast, Diversity Outbred (DO) mice are a new population whose level of genetic diversity is on par with that of humans and nonhuman primates (NHPs) . The eight founding inbred strains that comprised the initial breeding pool for DO mice included traditional laboratory strains such as B6 and A/J, as well as three wild-caught mouse … WebDiversity Outbred mice. Advantages. They reveal dominance and epistasis attributable to heterozygosity and randomized multi-locus combinations. More advanced …
WebTo overcome this critical issue, a mouse model, the Diversity Outbred (DO), was established that is genetically as diverse as the human population. In this study, we used …
WebAug 15, 2012 · The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display a broad range of phenotypes. Natural levels of heterozygosity provide genetic buffering and, as a result, DO mice are robust and breed … freedom church neosho moWebThe JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … freedom church lincolnton ncWebNov 20, 2024 · Additional insight has been gained from studies utilizing outbred mice to model genetic diversity present in the human population. Ag-driven changes in expression of CD8α and CD11a have been used as “surrogate activation markers” approach to track pathogen-specific CD8 T cell responses to infection in outbred mice without a priori ... freedom church moncks corner loud musicWebA genetically diverse mouse model is able to predict the range of response to chemical exposures that might be observed in human populations, researchers from the National … freedom church of god in christ norfolk vaWebEvaluate Diversity Outbred (DO) mice as a tool for exposure threshold assessment and for identification of genetic factors that influence benzene-induced genotoxicity. Appraise … bloody 20 indianaWebDiversity Outbred (J:DO) mice are a population of outbred animals with well-randomized genetic sequence polymorphisms and a genetic architecture similar to that of human … freedom church moncks cornerWebJan 17, 2024 · While both outbred stocks offer significant individual heterozygosity, our data provide a molecular basis for their intended applications, where the J:DO are best suited for studies requiring maximum, population-level genetic diversity and power for mapping, while the J:ARC are best suited as a general-purpose outbred stock with robust ... bloody32 playlist