Circwhsc1
WebNov 3, 2006 · We found that circWhsc1 was enriched in neonatal mouse hearts, particularly in cardiac ECs, and was further upregulated both in ECs and EC-derived EVs under hypoxic conditions. When cocultured with hypoxia-preconditioned neonatal ECs or their secreted EVs, both neonatal and adult CMs exhibited an increased proliferation rate and G2/M … WebMay 7, 2024 · Abstract Circular RNAs (circRNAs) play important roles in human cancer progression. Their high stability and tissue specificity make circRNAs important molecular targets for clinical diagnosis, tre...
Circwhsc1
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WebApr 29, 2024 · The enclosed configuration of circRNAs protects them from degradation and potentiates them as biomarkers. Several circRNAs such as circMUC16, circRNA_MYLK, circRNA-UBAP2, circWHSC1, hsa_circ_0013958, circFGFR3, hsa_circRNA_102958 and circ_0072995 have been found to be up-regulated in this cancer, acting as oncogenes. WebExosomal circWHSC1 can be transferred to peritoneal mesothelial cells and promotes peritoneal dissemination. Conclusions Our study demonstrates the highly expressed circWHSC1 in ovarian cancer promotes tumorigenesis by sponging miR-145 and miR-1182, and its exosome forms induce tumor metastasis through acting on peritoneal mesothelium.
WebCompared with the group transfected with control vector, overexpression of circWHSC1 in CAOV3 increased cell growth (a), reduced cell apoptosis (c), increased cell migration (e) and invasion rate (g).
WebDec 1, 2024 · CircWHSC1 overexpressed nude mice showed increased tumorigenicity. Bioinformatics predicted that circWHSC1 binds to miR‐646, which was confirmed using luciferase reporter gene assays. WebDec 31, 2024 · We found that circWhsc1 was enriched in neonatal mouse hearts, particularly in cardiac ECs, and was further upregulated both in ECs and EC-derived EVs under hypoxic conditions. When cocultured with hypoxia-preconditioned neonatal ECs or their secreted EVs, both neonatal and adult CMs exhibited an increased proliferation rate …
WebJan 6, 2024 · CircWHSC1 functioned as the sponge for miR‐142‐3p, which directly targeted HOXA1. Inhibition of miR‐142‐3p ameliorated the effects of circWHSC1 knockdown on HCC cell proliferation and metastasis. Moreover, miR‐142‐3p overexpression restrained the growth and motility of HCC cells, with HOXA1 elevation reversing the impacts. ...
WebDec 29, 2024 · CircWhsc1, a hypoxia-inducible circRNA, is highly expressed in cardiac ECs. (A) Screened circRNAs that are highly expressed in neonatal rodent hearts, … irishtown fire hall eventsWebDec 1, 2024 · CircWHSC1 [170] and circPUM1 [77] were reported to not only promote EOC cell proliferation, migration and invasion by sponging miRNAs but also act on the peritoneum in an exosome-dependent manner ... irishtown nature park mapWebboth circWHSC1 overexpressed and down-regulated cell lines were further selected with 2 μg/mL puromycin. The sequences of circWHSC1 and shRNA can be found in Additional file 1:TableS3. MTT assay The circWHSC1 overexpressed and down-regulated cells with control group were counted and seeded in 96-well plates. 0h, 24h, 48h and 72h after … port hammondWebJan 6, 2024 · CircWHSC1 functioned as the sponge for miR‐142‐3p, which directly targeted HOXA1. Inhibition of miR‐142‐3p ameliorated the effects of circWHSC1 knockdown on … port hamilton bermuda webcamWebJun 25, 2009 · 401 Wych Cir, Crestview, FL 32536 is a 3 bedroom, 2 bathroom, 1,802 sqft single-family home built in 2009. This property is not currently available for sale. 401 … port hampersWeb(D, E) MCF7 cells were transfected with miR-195-5p mimics and circWHSC1 overexpressing plasmids, and qRT-PCR was carried out to determine the expression of miR-195-5p (D) and circWHSC1 (E). irishtown nature parkWebMay 7, 2024 · CircWHSC1 expression in normal endometrial and endometrial cancer tissues was detected using PCR. Overexpression or knockdown of circWHSC1 in … irishtown nature park moncton